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Coadministration of encorafenib with sensitive CYP3A4 substrates may result in enhanced toxicity or diminished efficacy of those agents.diazepam will increase the level or influence of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate)